《Scientific Reports》：巖藻多糖具有延緩慢性腎衰的活性

延伸閱讀：

Sci. Rep. 7, 40183; doi: 10.1038/srep40183 (2017).

Oligo-fucoidan prevents renal tubulointerstitial fbrosis by inhibiting the CD44 signal pathway

Abstract:

Tubulointerstitial fbrosis is recognized as a key determinant of progressive chronic kidney disease (CKD). Fucoidan, a sulphated polysaccharide extracted from brown seaweed, exerts benefcial e?ects in some nephropathy models. The present study evaluated the inhibitory e?ect of oligo-fucoidan (800 Da) on renal tubulointerstitial fbrosis. We established a mouse CKD model by right nephrectomy with transient ischemic injury to the left kidney. Six weeks after the surgery, we fed the CKD mice oligo-fucoidan at 10, 20, and 100 mg/kg/d for 6 weeks and found that the oligo-fucoidan doses less than 100 mg/kg/d improved renal function and reduced renal tubulointerstitial fbrosis in CKD mice. Oligofucoidan also inhibited pressure-induced fbrotic responses and the expression of CD44, β-catenin, and TGF-β in rat renal tubular cells (NRK-52E). CD44 knockdown downregulated the expression of β-catenin and TGF-β in pressure-treated cells. Additional ligands for CD44 reduced the anti-fbrotic e?ect of oligofucoidan in NRK-52E cells. These data suggest that oligo-fucoidan at the particular dose prevents renal tubulointerstitial fbrosis in a CKD model. The anti-fbrotic e?ect of oligo-fucoidan may result from interfering with the interaction between CD44 and its extracellular ligands.

First Authors:

Cheng-Hsien Chen

Correspondence:

Tso-Hsiao Chen

All Authors:

Cheng-Hsien Chen, Yuh-Mou Sue, Chung-Yi Cheng, Yen-Cheng Chen, Chung-Te Liu, Yung-Ho Hsu, Pai-An Hwang, Nai-Jen Huang & Tso-Hsiao Chen

2017-01-18 Article