Hit (one) where it hurts (most):

To attack one in the area that is most vulnerable or that will result in the most harm. Usually does not refer to physical violence.

戳中要害 √

例句： 

The best way to take down the cartel is to hit them where it hurts most

打倒卡特爾的最好辦法是戳中他們的要害。

Know where (one) is going:

To have a clear knowledge of what one wants to be or achieve and the resolute determination to make it happen.

有明確的目標(biāo) √

例句：

Since she was a little girl, she knew where she was going—nothing was going to stop her from being a fighter pilot.

因?yàn)樗莻€(gè)小女孩，她很清楚自己的目標(biāo)，沒有什么能阻止她成為一名戰(zhàn)斗機(jī)飛行員。

Song for you（片尾曲）

ONE OK ROCK、Avril Lavigne - Listen