研究回顧性分析了本中心411例TA患者，探索其腎動脈受累患者的臨床特征。210例TA患者腎動脈受累，其中78.1%伴腎動脈狹窄。

與腎動脈未受累TA患者相比，腎動脈累及TA患者發(fā)病年齡較輕（23.5 vs 25.6歲），高血壓發(fā)病率更高（74.6% vs 28.1%），更易發(fā)生充血性心率衰竭（22.4% vs 7.6%）、肺動脈高壓（19.9% vs 9.5%）。隨著腎動脈狹窄程度的加重，腎小球?yàn)V過率（eGFR）逐漸降低。

發(fā)病年齡大于24歲、病程超過19個(gè)月、腎動脈受累是TA患者腎功能受損的獨(dú)立危險(xiǎn)因素。與腎動脈未受累TA患者相比，腎動脈受累TA患者的心腎功能不全更嚴(yán)重。腎小球率過濾與腎動脈狹窄程度呈負(fù)相關(guān)。

The renal artery is involved in Chinese Takayasu's arteritis patients 

Abstract

Takayasu's arteritis is a rare systemic vasculitis mainly affecting the aorta and its major branches. Previous studies have suggested that almost half of the Asian Takayasu's patients have renal artery involvement. However, due to the rarity of the disease, little is known about renal artery involvement in Chinese Takayasu's arteritis patients. Here, we retrospectively reviewed and analyzed 411 patients diagnosed with Takayasu's arteritis in our center to explore the clinical features of renal artery involvement in this group of patients. Of these, 201 patients were diagnosed to have renal artery involvement, with stenosis (78.1%) the most common renal artery pattern. Compared to those without, patients with renal artery involvement were significantly younger at disease onset (23.5 vs 25.6 years) and more frequently had hypertension (74.6% vs 28.1%). Congestive heart failure (22.4% vs 7.6%) and pulmonary hypertension (19.9% vs 9.5%) were both significantly more prevalent among patients with than those without renal artery involvement. The estimated glomerular filtration rate (eGFR) significantly decreased as the severity of renal artery stenosis increased. Age at disease onset older than 24 years (odds ratio 6.06 [95% Confidence Interval 2.76-13.3]), disease duration longer than 19 months (3.35 [1.52-7.4]) and renal artery involvement (8.7 [3.8-20.1]) were independent risk factors for renal dysfunction (eGFR under 90 mL/min/1.73m2) among patients with Takayasu's arteritis. Thus, patients with renal artery involvement have more severe cardiac and renal dysfunction compared to those without. The eGFR is correlated negatively with the severity of renal artery stenosis.

KEYWORDS:

Chinese; Takayasu’s arteritis; clinical features; renal artery involvement; renal function

譯者：李治琴 西臨床免疫科