*僅供醫(yī)學(xué)專業(yè)人士閱讀參考
尋常痤瘡是以毛囊皮脂腺單位的炎癥過程為特征的疾病，會(huì)影響80%～90%的青少年。
嚴(yán)重的痤瘡炎癥可導(dǎo)致遺留紅斑或色素沉著，甚至永久性的痤瘡瘢痕。
與活動(dòng)性痤瘡或痤瘡后瘢痕相比，痤瘡后紅斑也稱炎癥后紅斑（post-inflammatory ery-thema,PIE），是一種研究不足的痤瘡后遺癥，其臨床意義常被低估[1]。
對于惱人的紅痘印，今天跟大家盤點(diǎn)一下文獻(xiàn)中的前沿治療方法。
氨甲環(huán)酸
氨甲環(huán)酸（TXA）通過抑制促炎細(xì)胞素（IL-6和TNF-α）和新生血管形成來減少紅斑，已被用于治療紅斑型玫瑰痤瘡。
噻嗎洛爾
圖2. 馬來酸噻嗎洛爾治療前后對比（圖源參考文獻(xiàn)）
羥甲唑林
他克莫司
圖3. 他克莫司軟膏治療前后對比（圖源參考文獻(xiàn)）
聯(lián)合制劑
染料激光（PDL）
Nd：YAG激光
強(qiáng)脈沖光（IPL）
圖5. IPL 治療前后對比（圖源參考文獻(xiàn)）
射頻
皮秒激光
圖7. 皮秒激光治療前后對比（圖源參考文獻(xiàn)）
參考文獻(xiàn)：
[1]朱學(xué)娥,向芳,段曼曼等.微針射頻與強(qiáng)脈沖激光治療痤瘡后紅斑的療效比較[J].中國激光醫(yī)學(xué)雜志,2023,32(01):48-50.
[2]Jakhar D, Kaur I. Topical 5% tranexamic acid for acne-related postinflammatory erythema. J Am Acad Dermatol. 2020 Jun;82(6):e187-e188.
[3]Afra TP, Razmi T M, De D. Topical timolol for postacne erythema. J Am Acad Dermatol. 2021 Jun;84(6):e255-e256.
[4]Washrawirul C, Puaratana-Arunkon T, Chongpison Y,et,al. The role of the topical nasal decongestant oxymetazoline as a novel therapeutic option for post-acne erythema: A split-face, double-blind, randomized, placebo-controlled trial. J Dermatol. 2023 Feb 20.
[5]Mhatre M, Sharma A, Agrawal S. Topical tacrolimus for acne-related macular erythema to prevent atrophic scarring. J Am Acad Dermatol. 2022 Jun;86(6):e253-e254.
[6]Agamia N, El-Nagdy S, El-Ariny A. A split face comparative study using a novel triple combination therapy for the treatment of persistent post acne erythema. Dermatol Ther. 2022 Apr;35(4):e15327.
[7]Yoon HJ, Lee DH, Kim SO, et,al. Acne erythema improvement by long-pulsed 595-nm pulsed-dye laser treatment: a pilot study. J Dermatolog Treat. 2008;19(1):38-44.
[8]Chalermsuwiwattanakan N, Rojhirunsakool S, Kamanamool N, et,al. The comparative study of efficacy between 1064-nm long-pulsed Nd:YAG laser and 595-nm pulsed dye laser for the treatment of acne vulgaris. J Cosmet Dermatol. 2021 Jul;20(7):2108-2115.
[9]Wu X, Wang X, Wu X, et,al. Intense Pulsed Light Therapy Improves Acne-Induced Post-inflammatory Erythema and Hyperpigmentation: A Retrospective Study in Chinese Patients. Dermatol Ther (Heidelb). 2022 May;12(5):1147-1156.
[10]Min S, Park SY, Yoon JY, et,al. Fractional Microneedling Radiofrequency Treatment for Acne-related Post-inflammatory Erythema. Acta Derm Venereol. 2016 Jan;96(1):87-91.
[11]Wen X, Li Y, Hamblin MR, Jiang X. A randomized split-face, investigator-blinded study of a picosecond Alexandrite laser for post-inflammatory erythema and acne scars. Dermatol Ther. 2020 Nov;33(6):e13941.
[12]Jia X, Zheng L, Fang L, Zhang L, Wu Y, Yang Y, Feng Y, Huang L. Evaluation of the safety and efficacy of a fractional picosecond 1064 nm laser for post-acne erythema in adult Chinese patients. Skin Res Technol. 2023 Jan;29(1):e13274.
